Plasma treatment of biomedical materials

Junkar, Ita; Cvelbar, Uroš; Lehocký, Marián

dc.title	Plasma treatment of biomedical materials	en
dc.contributor.author	Junkar, Ita
dc.contributor.author	Cvelbar, Uroš
dc.contributor.author	Lehocký, Marián
dc.relation.ispartof	Materiali in Tehnologije
dc.identifier.issn	1580-2949 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2011
utb.relation.volume	45
utb.relation.issue	3
dc.citation.spage	221
dc.citation.epage	226
dc.type	article
dc.language.iso	en
dc.publisher	Institut za Kovinske Materiale in Tehnologije Ljubljana	sl
dc.relation.uri	http://mit.imt.si/Revija/mit113.html
dc.subject	plasma treatment	en
dc.subject	biocompatibility	en
dc.subject	polymer	en
dc.subject	vascular grafts	en
dc.subject	endothelia cells	en
dc.subject	platelets	en
dc.description.abstract	Surface plasma treatment techniques for modification of biomedical polymeric materials are presented. The emphasis is on the use of non-equilibrium radiofrequency (RF) oxygen and nitrogen plasma. By variation of discharge parameters (power, discharge frequency, type of gas) and plasma parameters (density of neutrals and ions, kinetic energy of electrons, gas temperature) it is possible to produce polymer surfaces with different surface properties. Already after short plasma treatment time the surface of polymeric material becomes hydrophilic. Formation of nitrogen and oxygen functional groups is observed immediately after plasma treatment. By optimisation of plasma treatment time the number of newly formed functional groups can be increased. Plasma treatment also produces morphological changes of the surface; nanohills of different shapes and height can be formed on PET surface depending on the treatment time and type of gas. Evidently the change in surface morphology affects the change in surface roughness, which increases with longer plasma treatment time. Plasma treatment influences also on the biological response, as all plasma treated surfaces exhibit improved proliferation of fibroblast and endothelia cells. The number of adherent platelets practically does not change after nitrogen plasma treatment, however much lower number of adherent platelets is observed on oxygen plasma treated surfaces.	en
utb.faculty	University Institute
dc.identifier.uri	http://hdl.handle.net/10563/1002190
utb.identifier.rivid	RIV/70883521:28610/11:43865318!RIV12-MSM-28610___
utb.identifier.obdid	43865320
utb.identifier.scopus	2-s2.0-79958004146
utb.identifier.wok	000291170700010
utb.source	j-wok
dc.date.accessioned	2011-08-16T15:06:38Z
dc.date.available	2011-08-16T15:06:38Z
dc.rights.uri	http://mit.imt.si/
dc.rights.access	openAccess
utb.ou	Centre of Polymer Systems
utb.contributor.internalauthor	Lehocký, Marián
utb.fulltext.affiliation	Ita Junkar1, Uroš Cvelbar2, Marian Lehocky3 1 Odsek za tehnologijo površin in optoelektroniko, Institut "Jožef Stefan", Jamova cesta 39, 1000 Ljubljana, Slovenija 2 Center of Excellence for Polymer Materials and Technologies, Tehnolo{ki park 24, 1000 Ljubljana, Slovenia 3 Medical Materials Research Centre, Technology Park, Tomas Bata University, Nad Ovcirnou 3685, Zlin, Czech Republic ita.junkar@ijs.si
utb.fulltext.dates	Prejem rokopisa – received: 2011-02-15 sprejem za objavo – accepted for publication: 2011-03-06
utb.fulltext.references	1 J. H. Joist, P D. Cennington, Transactions-American Society for Artificial Internal Organs, 33 (1987), 341 2 L. Vroman, Bulletin of the New York Academy of Medicine, 64 (1988), 352 3 T. Chandy, G. S. Das, R. F. Wilson, G. H. R. Rao, Biomaterials, 21 (2000), 699 4 J. H. Lee, G. Khang, J. W. Lee, Journal of Colloid and Interface Science, 205 (1998), 323 5 M. Chen, P. O. Zamora, P. Som, L. A. Pena, S. Osaki, J. Biomater. Sci. Polymer Edn 14 (2003) 9, 917–935 6 A. Asadinezhad, I. Novak, M. Lehocky, V. Sedlarik, A. Vesel, I. Junkar, P. Saha, I. Chodak, Irgasan coating, Plasma Processes and Polymers, 7 (2010) 6, 504–514 7 M. Lehocký, P. F. F. Amaral, P. Sahel, A. M. Z. Coelho, A. M. Barros-Timmons, J. A. P. Coutinho, Surface Engineering, 24 (2008), 23–27 8 M. Lehocký, L. Lapčík, R. Dlabaja, L. Rachunek, J. Stoch, Czechoslovak Journal of Physics, 54 (2004), 533–538 9 U. Cvelbar, M. Mozetic, I. Junkar, A. Vesel, J. Kovac, A. Drenik, T. Vrlinic, N. Hauptman, M. Klanjsek-Gunde, B. Markoli, N. Krstulovic, S. Milosevic, F. Gaboriau, T. Belmonte, Appl. Surf. Sci., 253 (2007) 21, 8669–8673 10 A. Vesel, M. Mozetic, A. Hladnik, J. Dolenc, J. Zule, S. Milosevic, N. Krstulovic, M. Klanjsek-Gunde, N. Hauptman, J. Phys. D: Appl. Phys., 40 (2007) 12, 3689–3696 11 M. Lehocký, H. Drnovská, B. Lapčíková, A.M. Barros – Timmons, T. Trindade, M. Zembala, L. Lapčík, Physicochemical and Engineering Aspects, 222 (2003), 125-131 12 A. Vesel, M. Mozetic, A. Zalar, Surf. Interface Anal., 40 (2008) 3–4, 661–663 13 M. Sowe, I. Novak, A. Vesel, I. Junkar, M. Lehocky, P. Saha, I. Chodak, Int. J. Polym. Anal. Ch., 14 (2009) 7, 641–651 14 M. Aouinti, P. Bertrand, F. Poncin-Epaillard, Plasmas Polym., 8 (2003) 4, 225–236 15 A. Vesel, M. Mozetic, S. Strnad, K. Stana-Kleinschek, N. Hauptman, Z. Persin, Vacuum, 84 (2010) 1, 79–82 16 J. G. Terlingen, L. M. Brenneisen, H. T. Super, A. P. Pijpers, A. S. Hoffman, J. Feijen, Journal of Biomaterials Science, 3 (1993), 165 17 A. Fridman, Plasma Chemistry, Cambridge University Press, New York, 2008 18 M. Venugopalan, Reaction under cold plasma conditions, Wiley/Interscience, New York, 1971 19 T. Vrlinic, A. Vesel, U. Cvelbar, M. Krajnc, M. Mozetic, Surf. Interface Anal., 39 (2007) 6, 476–481 20 A. Vesel, M. Mozetic, A. Zalar, Surf. Interface Anal., 40 (2008) 3–4, 661–663 21 A. Vesel, I. Junkar, U. Cvelbar, J. Kovac, M. Mozetic, Surf. Interface Anal., 40 (2008) 11, 1444–1453 22 A. Vesel, M. Mozetic, A. Zalar, Vacuum, 82 (2008) 2, 248–251 23 M. Sowe, I. Novak, A. Vesel, I. Junkar, M. Lehocky, P. Saha, I. Chodak, Int. J. Polym. Anal. Ch., 14 (2009) 7, 641–651 24 I. Junkar, U. Cvelbar, A. Vesel, N. Hauptman, M. Mozetic, Plasma Processes Polym., 6 (2009) 10, 667–675 25 M. Gorjanc, V. Bukosek, M. Gorensek, A. Vesel, Tex. Res. J., (2009), 1–11, doi:10.1177/0040517509348330 26 A. Vesel, M. Mozetic, S. Strnad, K. Stana - Kleinschek, N. Hauptman, Z. Persin, Vacuum, 84 (2010) 1, 79–82 27 I. Junkar, A. Vesel, U. Cvelbar, M. Mozetic, S. Strnad, Vacuum, 84 (2010) 1, 83–85 28 A. Asadinezhad, I. Novák, M. Lehocký, V. Sedlařík, A. Vesel, I. Junkar, P. Sáha, I. Chodák, Irgasan Coating, Plasma Processes and Polymers, 7 (2010), 504–514 29 J. López García, A. Asadinezhad, J. Pacherník, M. Lehocký, I. Junkar, P. Humpolíček, P. Sáha, P. Valášek, Molecules, 15 (2010), 2845–2856 30 A. Asadinezhad, I. Novák, M. Lehocký, V. Sedlařík, A.Vesel, I. Junkar, P. Sáha, I. Chodák, Colloids and Surfaces B: Biointerfaces, 77 (2010), 246–256 31 A. Asadinezhad,I. Novák, M. Lehocký, F. Bílek, A.Vesel, I. Junkar, P. Sáha, A. Popelka, Molecules, 15 (2010), 1007–1027 32 M. Lehocký, P. Sahel, M. Koutný, J. Čech, J. Institoris, A. Mráček, Journal of Materials Processing Technology, 209 (2009), 2871–2875 33 D.T. Clark, D.R. Hutton, J. Polym. Sci., A25 (1987), 2643 34 D. L. Mooradian, Trescony P, Keeney K, Furcht LT, J. Surg. Res., 53 (1992) 74 35 J. G. Steele, G. Johnson, C. McFarland, B. A. Dalton, T. R. Gengenbach, R. C. Chatelier, R. A. Underwood, H. J. Griesser, J. Biomaterial. Sci. Polymer, 6 (1994), 511 36 P. Chevallier, M. Castonguay, S. Turgeon, N. Dubrulle, D. Mantovani, P. H. McBreen, J. C. Wittmann, G. Laroche, J. Phys. Chem., B105 (2001), 12490–12497 37 I. Poberaj, M. Mozetic, D. Babic, Journal of Vacuum Science and Technology, A20 (2002), 189 38 D. Babic, I. Poberaj, M. Mozetic, Review of Scientific Instruments, 72 (2001), 4110 39 M. Mozetic, U. Cvelbar, A. Vesel, A. Ricard, D. Babic, I. Poberaj, Journal of Applied Physics 97 (2005), 103308 40 M. Mozetič, A. Vesel, U. Cvelbar, A. Ricard, Plasma Chemistry and Plasma Processing 26 (2006), 103 41 M. Mozetič Vacuum 71 (2003), 237–240 42 M. Mozetič B. Praček, Inf. MIDEM, 28 (1998), 171–174 43 M. Mozetič. Inf. MIDEM 28 (1998), 175–179 44 M. Drobnič, M. Mozetic, M. Gams, A. Zalar Vacuum 50 (1998), 50, 277–280 45 B. D. Ratner, A. Hoffman, F.J. Schoen, J.E. Lemons, Biomaterials Science, Academic Press, San Diego, 1996 46 D. Shi, Biomaterials and Tissue Engineering, Springer-Verlag, Berlin, 2004 47 V. Sedlarik, T. Galya, J. Sedlarikova, P. Valasek, P. Saha, Journal of Biomaterials Science-Polymer Edition, 21 (2010), 1421–1440 48 V. Sedlarik, T. Galya, J. Sedlarikova, P. Valasek, P. Saha, Journal of Biomaterials Science-Polymer Edition, 21 (2010), 1421–1440 49 Y. J. Kim, I. Kang, M.W. Huh, S. Yoon, Biomaterials 21 (2000), 121 50 M. C. Coen, R. Lehmann, P. Groening, L. Schlapbach, Applied Surface Science 207 (2003), 276 51 R. Tzoneva, B. Seifert, W. Albrecht, K. Richau, T. Groth, A. Lendlein, Journal of Material Science, 19 (2008), 3203 52 C. Sperling, R.B. Schweiss, U. Streller, C. Werner, Biomaterials, 26 (2005), 6547 53 B. Seifert, G. Mihanetzis, T. Groth, W. Albrecht, K. Richa, Y. Missirlis, D. Paul, G. Sengbusch, Artificial Organs, 26 (2002), 189 54 D. J. Wilson, R. L. Williams, R. C Pond, Surface Interface Analysis 31 (2001), 385 55 D. F. Williams, Advances in biomaterials, Elsevier, Amsterdam, 1988 56 T. A. Horbett, Cardiovascular Pathology, 2 (1993), 37 57 B. Montargent, D. Letourneur, Infection Control and Hospital Epidemiology, 21 (2000), 404 58 P. Roach, D. Farrar, C. C. Perry, Journal of the American Chemical Society, 127 (2005), 8168 59 L. Vroman, Bulletin of the New York Academy of Medicine, 64 (1988), 352 60 J. H. Lee, H. B. Lee, Journal of Biomedical Material Research, 41 (1998), 304 61 J. H. Choe, S. J. Lee, Y. M. Rhee, H. B. Lee, G. Khang, Journal of Applied Polymer Science, 92 (2004), 599 62 N. Faucheux, R. Schweiss, K. Lutzow, C. Werner, T. Groth, Biomaterials, 25 (2004), 2721 63 K. C. Dee, D. A. Puelo, R. Bizius, An introduction to tissuebiomaterial interactions, Hoboken, John Wiley & Sons, New Jersey, 2002 64 A. Kongde, T. Bechtold, L. Teufel, Journal Applied Polymer Scienc, 96 (2005), 1421 65 L. C. Xu, C. Siedlecki, A. Christopher, Biomaterials, 28 (2007), 3273 66 M. Reidel, B. Muller, E. Wintermantel, Biomaterials, 22 (2001), 2307 67 A. A. Vertegel, R. W. Siegel, J. S. Dordick, Langmuir, 20 (2004), 6800 68 M. J. Dalby, M. O. Riehle, H. Johnstone, S. Affrossman, A. S. G. Curtis, Biomaterials, 23 (2002), 2945 69 A. Curtis, C. Wilkinson, Biochemical Society Symposia, 65 (1999), 15 70 P. A. Ramires, L. Mirenghi, A. R. Romano, F. Palumbo, G. Nicolardi, Journal of Biomedical Material Research, 51 (2000), 535
utb.fulltext.sponsorship	The authors acknowledge the financial support from the Ministry of Higher Education, Science and Technology of the Republic of Slovenia through the contract No. 3211-10-000057 (Center of Excellence Polymer Materials and Technologies).
utb.fulltext.projects	3211-10-000057