Influence of temperature, pH and simulated biological solutions on swelling and structural properties of biomineralized (CaCO3) PVP-CMC hydrogel

Abstract

Biomaterials having stimuli response are interesting in the biomedical field. This paper reports about swelling response and internal structural of biomineralized (CaCO3) polyvinylpyrrolidone (PVP) carboxymethylcellulose (CMC) hydrogel having various thicknesses (0.1-0.4 mm). Samples were tested in aqueous solution using temperature ranges from 10 to 40 degrees C; pH varies from 4 to 9, time 60 min. In addition, an experiment was conducted in the presence of simulated biological solutions (SBS): glucose (GS), physiological fluid (PS) and urea US) at temperature 37 degrees C and pH 7.5 for 180 min. It is noticed that the maximum swelling ratio reached in 30-40 degrees C at pH 7 in aqueous solution. Among biological fluids, the swelling ratio shows: US[PS[GS at temperature 37 degrees C, pH 7.5, time 150 min. The equilibrium swelling ratio of the test sample in SBS and their non-reformative apparent structure confirm that biomineralized (CaCO3) PVP-CMC hydrogel can be acclaimed for medical application like bone tissue engineering.