Quercetin and its anti-allergic immune response

Mlček, Jiří; Juríková, Tünde; Škrovánková, Soňa; Sochor, Jiří

dc.title	Quercetin and its anti-allergic immune response	en
dc.contributor.author	Mlček, Jiří
dc.contributor.author	Juríková, Tünde
dc.contributor.author	Škrovánková, Soňa
dc.contributor.author	Sochor, Jiří
dc.relation.ispartof	Molecules
dc.identifier.issn	1420-3049 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2016
utb.relation.volume	21
utb.relation.issue	5
dc.type	review
dc.language.iso	en
dc.publisher	MDPI AG
dc.identifier.doi	10.3390/molecules21050623
dc.relation.uri	http://www.mdpi.com/1420-3049/21/5/623
dc.subject	Anti-allergic effect	en
dc.subject	Anti-inflammatory properties	en
dc.subject	Flavonoids	en
dc.subject	Immune response	en
dc.subject	Quercetin	en
dc.description.abstract	Quercetin is the great representative of polyphenols, flavonoids subgroup, flavonols. Its main natural sources in foods are vegetables such as onions, the most studied quercetin containing foods, and broccoli; fruits (apples, berry crops, and grapes); some herbs; tea; and wine. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. It can improve the Th1/Th2 balance, and restrain antigen-specific IgE antibody formation. It is also effective in the inhibition of enzymes such as lipoxygenase, eosinophil and peroxidase and the suppression of inflammatory mediators. All mentioned mechanisms of action contribute to the anti-inflammatory and immunomodulating properties of quercetin that can be effectively utilized in treatment of late-phase, and late-late-phase bronchial asthma responses, allergic rhinitis and restricted peanut-induced anaphylactic reactions. Plant extract of quercetin is the main ingredient of many potential anti-allergic drugs, supplements and enriched products, which is more competent in inhibiting of IL-8 than cromolyn (anti-allergic drug disodium cromoglycate) and suppresses IL-6 and cytosolic calcium level increase. © 2016 by the authors; licensee MDPI.	en
utb.faculty	Faculty of Technology
dc.identifier.uri	http://hdl.handle.net/10563/1006531
utb.identifier.obdid	43875200
utb.identifier.scopus	2-s2.0-84973923072
utb.identifier.wok	000380241600087
utb.identifier.coden	MOLEF
utb.source	j-scopus
dc.date.accessioned	2016-08-09T14:02:54Z
dc.date.available	2016-08-09T14:02:54Z
dc.description.sponsorship	internal grant agency of Tomas Bata University in Zlin [IGA/FT/2016/008, IGA ZF 2016]
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.rights.access	openAccess
utb.contributor.internalauthor	Mlček, Jiří
utb.contributor.internalauthor	Škrovánková, Soňa
utb.fulltext.affiliation	Jiri Mlcek 1,, Tunde Jurikova 2, Sona Skrovankova 1 and Jiri Sochor 3 1 Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, CZ-760 01 Zlín, Czech Republic; skrovankova@ft.utb.cz 2 Institute for Teacher Training, Faculty of Central European Studies, Constantine the Philosopher University in Nitra, Drazovska 4, SK-949 74 Nitra, Slovakia; tjurikova@ukf.sk 3 Department of Viticulture and Enology, Faculty of Horticulture, Mendel University in Brno, Valticka 337, CZ-691 44 Lednice, Czech Republic; sochor.jirik@seznam.cz Correspondence: mlcek@ft.utb.cz; Tel.: +420-57-603-3030 Academic Editor: Norbert Latruffe
utb.fulltext.dates	Received: 22 February 2016; Accepted: 3 May 2016; Published: 12 May 2016
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utb.fulltext.sponsorship	This study was funded by internal grant agency of Tomas Bata University in Zlín, project no. IGA/FT/2016/008 and IGA ZF 2016.
utb.fulltext.projects	IGA/FT/2016/008
utb.fulltext.projects	IGA ZF 2016