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Effect of plasma treatment on the release kinetics of a chemotherapy drug from biodegradable polyester films and polyester urethane films

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dc.title Effect of plasma treatment on the release kinetics of a chemotherapy drug from biodegradable polyester films and polyester urethane films en
dc.contributor.author Stloukal, Petr
dc.contributor.author Novák, Igor
dc.contributor.author Mičušík, Matej
dc.contributor.author Procházka, Michal
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Chodák, Ivan
dc.contributor.author Lehocký, Marián
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof International Journal of Polymeric Materials and Polymeric Biomaterials
dc.identifier.issn 0091-4037 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2018
utb.relation.volume 67
utb.relation.issue 3
dc.citation.spage 161
dc.citation.epage 173
dc.type article
dc.language.iso en
dc.publisher Taylor and Francis Inc.
dc.identifier.doi 10.1080/00914037.2017.1309543
dc.relation.uri https://www.tandfonline.com/doi/full/10.1080/00914037.2017.1309543
dc.subject Biodegradable materials en
dc.subject capacitively coupled radio frequency plasma en
dc.subject control release en
dc.subject diffuse coplanar surface barrier discharge en
dc.subject plasma treatments en
dc.description.abstract Investigation was made into the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and polyester urethane. The authors utilized two systems to achieve this, the first being diffuse coplanar surface barrier discharge, applying air as the gaseous medium, while the other involved capacitively coupled radio frequency discharge plasma under an argon atmosphere with hexamethyldisiloxane. Results showed that both forms of plasma treatment positively reduced the undesirable burst effect and benefited the release rate of TMZ. The hydrolytic degradability of the materials was slightly enhanced following hydrophilization, whereas the same diminished after hydrophobization had taken place. This was especially true for PLA due to modification of its wettability. © 2017 Taylor & Francis. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1007673
utb.identifier.obdid 43879619
utb.identifier.scopus 2-s2.0-85029676535
utb.identifier.wok 000428134500004
utb.identifier.coden IJPMC
utb.source j-scopus
dc.date.accessioned 2018-01-15T16:31:38Z
dc.date.available 2018-01-15T16:31:38Z
dc.description.sponsorship 02/0199/14, VEGA, Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; APVV-14-0518, APVV, Agentúra na Podporu Výskumu a Vývoja; QJ1310254, MZe, Ministerstvo Zemědělství; SAV, Slovenská Akadémia Vied; 15-08287Y, GACR, Grantová Agentura České Republiky; CZ.1.05/2.1.00/19.0409; LO1504
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Agriculture of the Czech Republic [QJ1310254]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504, CZ.1.05/2.1.00/19.0409]; Ministry of Education, Science, Research and Sports of the Slovak Republic; Slovak Academy of Sciences, as a part of the "VEGA" project [02/0199/14]; Slovak Research and Development Agency [APVV-14-0518]
dc.rights.uri https://authorservices.taylorandfrancis.com/publishing-open-access/oa-options-finder/
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Stloukal, Petr
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Petr Stloukal1,, Igor Novák2, Matej Mičušík2, Michal Procházka2, Pavel Kucharczyk1, Ivan Chodák2, Marian Lehocký1, Vladimír Sedlařík1 1 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, tř. T. Bati, Zlín, Czech Republic, 2 Polymer Institute, Slovak Academy of Sciences, Dubravská cesta, Bratislava, Slovak Republic Corresponding author: Petr Stloukal, E-mail: StloukalP@seznam.cz
utb.fulltext.dates Received 28 Dec 2016, Accepted 18 Mar 2017, Accepted author version posted online: 24 Apr 2017, Published online: 01 Dec 2017
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utb.fulltext.sponsorship This work was financially supported by the Czech Science Foundation (Grant No. 15-08287Y), the Ministry of Agriculture of the Czech Republic (Grant No. QJ1310254) and the Ministry of Education, Youth and Sports of the Czech Republic (GrantsNo. LO1504 and CZ.1.05/2.1.00/19.0409). The work was also supported by the Ministry of Education, Science, Research and Sports of the Slovak Republic and the Slovak Academy of Sciences, as part of the “VEGA” project (ref. 02/0199/14) and by the Slovak Research and Development Agency under contract No. APVV-14-0518
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University, Zlín, Czech Republic; Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia
utb.fulltext.projects 15-08287Y
utb.fulltext.projects QJ1310254
utb.fulltext.projects LO1504
utb.fulltext.projects CZ.1.05/2.1.00/19.0409
utb.fulltext.projects VEGA 02/0199/14
utb.fulltext.projects APVV-14-0518
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