Polyaniline cryogels: Biocompatibility of novel conducting macroporous material

Humpolíček, Petr; Radaszkiewicz, Katarzyna Anna; Capáková, Zdenka; Pacherník, Jiri; Bober, Patrycja; Kašpárková, Věra; Rejmontová, Petra; Lehocký, Marián; Ponížil, Petr; Stejskal, Jaroslav

dc.title	Polyaniline cryogels: Biocompatibility of novel conducting macroporous material	en
dc.contributor.author	Humpolíček, Petr
dc.contributor.author	Radaszkiewicz, Katarzyna Anna
dc.contributor.author	Capáková, Zdenka
dc.contributor.author	Pacherník, Jiri
dc.contributor.author	Bober, Patrycja
dc.contributor.author	Kašpárková, Věra
dc.contributor.author	Rejmontová, Petra
dc.contributor.author	Lehocký, Marián
dc.contributor.author	Ponížil, Petr
dc.contributor.author	Stejskal, Jaroslav
dc.relation.ispartof	Scientific Reports
dc.identifier.issn	2045-2322 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2018
utb.relation.volume	8
utb.relation.issue	1
dc.type	article
dc.language.iso	en
dc.publisher	Nature Publishing Group
dc.identifier.doi	10.1038/s41598-017-18290-1
dc.relation.uri	https://www.nature.com/articles/s41598-017-18290-1
dc.description.abstract	Polyaniline cryogel is a new unique form of polyaniline combining intrinsic electrical conductivity and the material properties of hydrogels. It is prepared by the polymerization of aniline in frozen poly(vinyl alcohol) solutions. The biocompatibility of macroporous polyaniline cryogel was demonstrated by testing its cytotoxicity on mouse embryonic fibroblasts and via the test of embryotoxicity based on the formation of beating foci within spontaneous differentiating embryonic stem cells. Good biocompatibility was related to low contents of low-molecular-weight impurities in polyaniline cryogel, which was confirmed by liquid chromatography. The adhesion and growth of embryonic stem cells, embryoid bodies, cardiomyocytes, and neural progenitors prove that polyaniline cryogel has the potential to be used as a carrier for cells in tissue engineering or bio-sensing. The surface energy as well as the elasticity and porosity of cryogel mimic tissue properties. Polyaniline cryogel can therefore be applied in bio-sensing or regenerative medicine in general, and mainly in the tissue engineering of electrically excitable tissues. © 2017 The Author(s).	en
utb.faculty	University Institute
utb.faculty	Faculty of Technology
dc.identifier.uri	http://hdl.handle.net/10563/1007736
utb.identifier.obdid	43879620
utb.identifier.scopus	2-s2.0-85040452403
utb.identifier.wok	000419659600016
utb.source	j-scopus
dc.date.accessioned	2018-02-26T10:20:03Z
dc.date.available	2018-02-26T10:20:03Z
dc.description.sponsorship	Czech Science Foundation [17-05095S]; Ministry of Education, Youth and Sports of the Czech Republic - Program NPU I [LO1504]; European Regional Development Fund [CZ.1.05/2.1.00/19.0409]
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.rights.access	openAccess
utb.ou	Centre of Polymer Systems
utb.contributor.internalauthor	Humpolíček, Petr
utb.contributor.internalauthor	Capáková, Zdenka
utb.contributor.internalauthor	Kašpárková, Věra
utb.contributor.internalauthor	Rejmontová, Petra
utb.contributor.internalauthor	Lehocký, Marián
utb.contributor.internalauthor	Ponížil, Petr
utb.fulltext.affiliation	Petr Humpolíček http://orcid.org/0000-0002-6837-6878 1,2 , Katarzyna Anna Radaszkiewicz 3 , Zdenka Capáková 1 , Jiří Pacherník 3 , Patrycja Bober 4 , Věra Kašpárková 1,2 , Petra Rejmontová 1,2 , Marián Lehocký 1,2 , Petr Ponížil 1,2 & Jaroslav Stejskal 4 1 Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01, Zlin, Czech Republic. 2 Faculty of Technology, Tomas Bata University in Zlin, 760 01, Zlin, Czech Republic. 3 Institute of Experimental Biology, Faculty of Science, Masaryk University, 625 00, Brno, Czech Republic. 4 Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06, Prague 6, Czech Republic. Correspondence and requests for materials should be addressed to P.H. (email: humpolicek@utb.cz)
utb.fulltext.dates	Received: 8 August 2017 Accepted: 5 December 2017 Published: 09 January 2018
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utb.fulltext.sponsorship	This work was supported by the Czech Science Foundation (17-05095S), and by the Ministry of Education, Youth and Sports of the Czech Republic – Program NPU I (LO1504). The European Regional Development Fund (Grant CZ.1.05/2.1.00/19.0409) is thanked for thermal conductivity analyser (C-term technologies, model TCi).
utb.wos.affiliation	[Humpolicek, Petr; Capakova, Zdenka; Kasparkova, Vera; Rejmontova, Petra; Lehocky, Marian; Ponizil, Petr] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Humpolicek, Petr; Kasparkova, Vera; Rejmontova, Petra; Lehocky, Marian; Ponizil, Petr] Tomas Bata Univ Zlin, Fac Technol, Zlin 76001, Czech Republic; [Radaszkiewicz, Katarzyna Anna; Pachernik, Jiri] Masaryk Univ, Fac Sci, Inst Expt Biol, Brno 62500, Czech Republic; [Bober, Patrycja; Stejskal, Jaroslav] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague 6, Czech Republic
utb.scopus.affiliation	Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, Zlin, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague 6, Czech Republic
utb.fulltext.projects	17-05095S
utb.fulltext.projects	NPU I (LO1504)
utb.fulltext.projects	CZ.1.05/2.1.00/19.0409