Risk profile analysis and complications after surgery for autoimmune thyroid disease

Thomusch, Oliver; Sekulla, C.; Billmann, F.; Seifert, G.; Dralle, H.; Lorenz, K.; Vorländer, C.; Dralle, H.; Freitag, M.; Jähne, J.; Steinmüller, T.; Trupka, A.; Steinert, F.; Schabram, J.; Heinzmann, B.; Lang, H.; Cotte, J.; Hoffmann, T.F.; Dette, K.; Gellert, K.; Henne-Bruns, D.; Boese-Landgraf, J.; Simon Evangelisches, D.; Kube, R.; Lorenz, E.P.M.; Pross, M.; Hartel, M.; Thomschke, D.; Pistorius, G.; Hopt, U.T.; Franke, C.; Rose, U.; Steuer, W.; Schwenk, W.; Ebert, K.-H.; Kelm, C.; Witzigmann, H.; Rampf, W.; Ridwelski, K.; Knoefel, W.T.; Bechstein, W.O.; Grothe, D.; Anthuber, M.; Mirow, L.; Probst, W.; Thews, A.; Fleck, U.; Kärgel, W.; Schimmelpenning, H.; Fielitz, J.; Rose, U.; Schöffauer, T.; Asperger, W.; Zaage, J.; Dorn, H.-U.; Weitz, J.; Neubauer, M.; Klar, E.; Lautermann, J.; Senkal, M.; Lippert, H.; Lück, R.; Ziesche, M.; Kröll, K.-P.; Skrobisz, J.; Lorenc, Z.; Dudešek, Bohumil; Smutny, S.; Brauckhoff, M.; Längle, F.; Wenzl, E.; the Prospective Evaluation Study of Thyroid Surgery (PETS 2) Study Group

dc.title	Risk profile analysis and complications after surgery for autoimmune thyroid disease	en
dc.contributor.author	Thomusch, Oliver
dc.contributor.author	Sekulla, C.
dc.contributor.author	Billmann, F.
dc.contributor.author	Seifert, G.
dc.contributor.author	Dralle, H.
dc.contributor.author	Lorenz, K.
dc.contributor.author	Vorländer, C.
dc.contributor.author	Dralle, H.
dc.contributor.author	Freitag, M.
dc.contributor.author	Jähne, J.
dc.contributor.author	Steinmüller, T.
dc.contributor.author	Trupka, A.
dc.contributor.author	Steinert, F.
dc.contributor.author	Schabram, J.
dc.contributor.author	Heinzmann, B.
dc.contributor.author	Lang, H.
dc.contributor.author	Cotte, J.
dc.contributor.author	Hoffmann, T.F.
dc.contributor.author	Dette, K.
dc.contributor.author	Gellert, K.
dc.contributor.author	Henne-Bruns, D.
dc.contributor.author	Boese-Landgraf, J.
dc.contributor.author	Simon Evangelisches, D.
dc.contributor.author	Kube, R.
dc.contributor.author	Lorenz, E.P.M.
dc.contributor.author	Pross, M.
dc.contributor.author	Hartel, M.
dc.contributor.author	Thomschke, D.
dc.contributor.author	Pistorius, G.
dc.contributor.author	Hopt, U.T.
dc.contributor.author	Franke, C.
dc.contributor.author	Rose, U.
dc.contributor.author	Steuer, W.
dc.contributor.author	Schwenk, W.
dc.contributor.author	Ebert, K.-H.
dc.contributor.author	Kelm, C.
dc.contributor.author	Witzigmann, H.
dc.contributor.author	Rampf, W.
dc.contributor.author	Ridwelski, K.
dc.contributor.author	Knoefel, W.T.
dc.contributor.author	Bechstein, W.O.
dc.contributor.author	Grothe, D.
dc.contributor.author	Anthuber, M.
dc.contributor.author	Mirow, L.
dc.contributor.author	Probst, W.
dc.contributor.author	Thews, A.
dc.contributor.author	Fleck, U.
dc.contributor.author	Kärgel, W.
dc.contributor.author	Schimmelpenning, H.
dc.contributor.author	Fielitz, J.
dc.contributor.author	Rose, U.
dc.contributor.author	Schöffauer, T.
dc.contributor.author	Asperger, W.
dc.contributor.author	Zaage, J.
dc.contributor.author	Dorn, H.-U.
dc.contributor.author	Weitz, J.
dc.contributor.author	Neubauer, M.
dc.contributor.author	Klar, E.
dc.contributor.author	Lautermann, J.
dc.contributor.author	Senkal, M.
dc.contributor.author	Lippert, H.
dc.contributor.author	Lück, R.
dc.contributor.author	Ziesche, M.
dc.contributor.author	Kröll, K.-P.
dc.contributor.author	Skrobisz, J.
dc.contributor.author	Lorenc, Z.
dc.contributor.author	Dudešek, Bohumil
dc.contributor.author	Smutny, S.
dc.contributor.author	Brauckhoff, M.
dc.contributor.author	Längle, F.
dc.contributor.author	Wenzl, E.
dc.contributor.author	the Prospective Evaluation Study of Thyroid Surgery (PETS 2) Study Group
dc.relation.ispartof	British Journal of Surgery
dc.identifier.issn	0007-1323 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2018
utb.relation.volume	105
utb.relation.issue	6
dc.citation.spage	677
dc.citation.epage	685
dc.type	article
dc.language.iso	en
dc.publisher	John Wiley and Sons Ltd.
dc.identifier.doi	10.1002/bjs.10770
dc.relation.uri	https://onlinelibrary.wiley.com/doi/abs/10.1002/bjs.10770
dc.description.abstract	Background: Surgical approaches to autoimmune thyroid disease are currently hampered by concerns over postoperative complications. Risk profiles and incidences of postoperative complications have not been investigated systematically, and studies with sufficient power to show valid data have not been performed. Methods: A prospective multicentre European study was conducted between July 2010 and December 2012. Questionnaires were used to collect data prospectively on patients who had surgery for autoimmune thyroid disease and the findings were compared with those of patients undergoing surgery for multinodular goitre. Logistic regression analysis was used to evaluate risk factors for thyroid surgery-specific complications, transient and permanent recurrent laryngeal nerve (RLN) palsy and hypoparathyroidism. Results: Data were available for 22 011 patients, of whom 18 955 were eligible for analysis (2488 who had surgery for autoimmune thyroid disease and 16 467 for multinodular goitre). Surgery for multinodular goitre and that for autoimmune thyroid disease did not differ significantly with regard to general complications. With regard to thyroid surgery-specific complications, the rate of temporary and permanent vocal cord palsy ranged from 2·7 to 6·7 per cent (P = 0·623) and from 0·0 to 1·4 per cent (P = 0·600) respectively, whereas the range for temporary and permanent hypoparathyroidism was 12·9 to 20·0 per cent (P < 0·001) and 0·0 to 7·0 per cent (P < 0·001) respectively. In logistic regression analysis of transient and permanent vocal cord palsy, autoimmune thyroid disease was not an independent risk factor. Autoimmune thyroid disease, extent of thyroid resection, number of identified parathyroid glands and no autotransplantation were identified as independent risk factors for both transient and permanent hypoparathyroidism. Conclusion: Surgery for autoimmune thyroid disease is safe in comparison with surgery for multinodular goitre in terms of general complications and RLN palsy. To avoid the increased risk of postoperative hypoparathyroidism, special attention needs to be paid to the parathyroid glands. © 2018 BJS Society Ltd Published by John Wiley & Sons Ltd	en
utb.faculty	Faculty of Humanities
dc.identifier.uri	http://hdl.handle.net/10563/1007889
utb.identifier.obdid	43878348
utb.identifier.scopus	2-s2.0-85044443801
utb.identifier.pubmed	29579336
utb.identifier.coden	BJSUA
utb.source	j-scopus
dc.date.accessioned	2018-05-18T15:12:04Z
dc.date.available	2018-05-18T15:12:04Z
dc.description.sponsorship	Stiftelserna Wilhelm och Martina Lundgrens
utb.contributor.internalauthor	Dudešek, Bohumil
utb.fulltext.affiliation	O. Thomusch1 , C. Sekulla2, F. Billmann3, G. Seifert1, H. Dralle2 and K. Lorenz2, on behalf of the Prospective Evaluation Study of Thyroid Surgery (PETS 2) Study Group 1 Department of General and Visceral Surgery, Albert Ludwig University of Freiburg, Freiburg, 2 Department of General, Vascular and Visceral Surgery, Martin Luther University of Halle-Wittenberg, Halle an der Saale, and 3 Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany Correspondence to: Professor O. Thomusch, Department of General and Visceral Surgery, Albert Ludwig University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany (e-mail: oliver.thomusch@uniklinik-freiburg.de)
utb.fulltext.dates	Paper accepted 25 October 2017
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utb.fulltext.sponsorship	O.T and C.S. contributed equally to this publication. The study received financial support from the Wilhelm Roux Foundation of Martin Luther University of HalleWittenberg. Disclosure: The authors declare no conflict of interest.
utb.scopus.affiliation	Department of General and Visceral Surgery, Albert Ludwig University of Freiburg, Freiburg, Germany; Department of General, Vascular and Visceral Surgery, Martin Luther University of Halle-Wittenberg, Halle an der Saale, Germany; Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany; Department of Endocrine Surgery, Bürgerhospital Frankfurt am Main, Germany; Department of General, Visceral and Vascular Surgery, University Hospital Halle/Saale, Germany; Department of Surgery, Hospital St Josef-Stift, Dresden, Germany; Department of Surgery, Henriettenstiftung, Hannover, Germany; Department of General Surgery, DRK Hospitals Berlin, Germany; Department of Surgery, Hospital Starnberg, Germany; Department of General and Visceral Surgery, HELIOS Hospital Schkeuditz, Germany; Department of General and Visceral Surgery, St Josef's Hospital Giessen, Germany; Department of Surgery, Hospital St Marienstift Magdeburg, Germany; Department of General and Visceral Surgery, University Hospital of Mainz, Germany; Department of Thyroid Surgery, Eichsfeld Hospital, Reifenstein, Italy; Department of Surgery, Maria Theresia Hospital, Munich, Germany; Department of Surgery, Vivantes Wenckebach-Hospital, Berlin, Germany; Department of General and Visceral Surgery, Sana Hospital Lichtenberg, Berlin-, Lichtenberg, Germany; Department of General, Visceral and Transplantation Surgery, University Hospital of Ulm, Germany; Department of General and Visceral Surgery, Hospital Chemnitz, Germany; Department of General and Visceral Surgery, Bethesda Johanniter Hospital Duisburg, Germany; Department of Surgery, Carl-Thiem-Hospital Cottbus, Germany; Department of Surgery, St Hedwig Hospital Berlin, Germany; Department of Surgery, DRK Hospital Berlin Köpenick, Berlin, Germany; Department of Surgery, Hospital Dortmund, Germany; Department of General and Visceral Surgery, Hospital Kulmbach, Germany; Department of General and Visceral and Thoracic Surgery, Hospital Sozialstiftung Bamberg, Germany; Department of General and Visceral Surgery, University Hospital of Freiburg, Germany; Department of Surgery, Sana Hospital Benrath, Düsseldorf, Germany; Department of Surgery, Diakonie Hospital Halle, Germany; Department of Visceral Surgery, Westpfalz Hospital, Kaiserslautern, Germany; Department of General and Visceral Surgery, Asklepios Hospital Altona, Hamburg, Germany; Section of Surgery, St Martinus Hospital Olpe, Katholische Hospitalgesellschaft Südwestfalen, Olpe, Germany; Department of General and Visceral Surgery, Hospital Lüdenscheid, Germany; Department of General and Visceral Surgery, Städtisches Hospital Dresden Friedrichstadt, Dresden, Germany; Department of Surgery, Hospital 14 Nothelfer, Weingarten, Germany; Department of General and Visceral Surgery, Hospital Magdeburg, Germany; Department of General and Visceral Surgery, University Hospital of Düsseldorf, Germany; Department of General and Visceral Surgery, University Hospital of Universitätsklinikum Frankfurt am Main, Germany; Department of General and Visceral Surgery, Christliches Hospital Melle, Germany; Department of General, Visceral and Transplantation Surgery, Hospital Augsburg, Germany; Department of General and Visceral Surgery, Landkreis Mittweida Hospital, Mittweida, Germany; Department of General and Visceral Surgery, Ammerland Hospital, Westerstede, Germany; Department of Surgery, Hospital Schönebeck, Germany; Department of General and Visceral Surgery, DRK Hospital Luckenwalde, Germany; Klinik für Allgemein- und Visceralchirurgie, Klinikum Niederlausitz, Senftenberg, Germany; Department of General and Visceral Surgery, Hospital Neustadt, Germany; Department of Surgery, Paracelsus Hospital Reichenbach, Germany; Department of General, Visceral and Vascular Surgery, Hospital Martha Maria Halle Dölau, Halle/Saale, Germany; Department of Surgery, Oder Spree Hospital, Beeskow, Germany; Department of General and Visceral Surgery, Hospital St Elisabeth and St Barbara, Halle/Saale, Germany; Department of General Surgery, Hospital Bergmannstrost, Halle/Saale, Germany; Department of General and Visceral Surgery, Hospital Mittleres Erzgebirge Zschopau, Germany; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany; Department of Surgery, Hospital Freiberg, Germany; Department of General, Thoracic, Vascular and Transplantation Surgery, University Hospital of Rostock, Germany; Department of Ear, Nose and Throat Surgery, Hospital Martha Maria Halle-Dölau, Halle/Saale, Germany; Department of General and Visceral Surgery, Marien Hospital Witten, Germany; Department of General, Visceral and Vascular Surgery, University Hospital of Otto von Guericke University, Magdeburg, Germany; Department of General and Visceral Surgery, Sana Hospital Hameln-Pyrmont, Hameln, Germany; Department of General and Visceral Surgery, Suedharz Hospital Nordhausen, Germany; Department of General and Visceral Surgery, Hochwaldkrankenhaus, Bad Nauheim, Germany; Oddział Chirurgii Ogólnej, Szpital Wojewódzki w Poznaniu, Poznań, Poland; Specjalistyczny Nr 5 im. św. Barbary, Wojewódzki Szpital, Sosnowiec, Germany; Tomáš Bat'a University, Zlín, Czech Republic; Department of Surgery, Oblastni nemocnice Pribram, Germany; Department of Surgery, University of Bergen Haukeland University Hospital, Bergen, Norway; Department of Surgery, Hospital Vienna Neustadt, Austria; Department of General and Thoracic Surgery, Landeskrankenhaus Feldkirch, Germany
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