Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents

Di Martino, Antonio; Trusova, Marina Evgenievna; Postnikov, Pavel S.; Sedlařík, Vladimír

dc.title	Folic acid-chitosan-alginate nanocomplexes for multiple delivery of chemotherapeutic agents	en
dc.contributor.author	Di Martino, Antonio
dc.contributor.author	Trusova, Marina Evgenievna
dc.contributor.author	Postnikov, Pavel S.
dc.contributor.author	Sedlařík, Vladimír
dc.relation.ispartof	Journal of Drug Delivery Science and Technology
dc.identifier.issn	1773-2247 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2018
utb.relation.volume	47
dc.citation.spage	67
dc.citation.epage	76
dc.type	article
dc.language.iso	en
dc.publisher	Editions de Sante
dc.identifier.doi	10.1016/j.jddst.2018.06.020
dc.relation.uri	https://www.sciencedirect.com/science/article/pii/S1773224718302910
dc.subject	alginic acid sodium salt	en
dc.subject	chitosan	en
dc.subject	Doxorubicin	en
dc.subject	doxorubicin hydrochloride	en
dc.subject	Folic acid	en
dc.subject	folic acid	en
dc.subject	Polysaccharides	en
dc.subject	Polytherapy	en
dc.subject	Targeting	en
dc.subject	Temozolomide	en
dc.subject	temozolomide	en
dc.description.abstract	A major challenge faced by researchers involved in the sphere of drug delivery is the development of innovative multidrug delivery systems. Herein, experimentation focused on preparing nanocomplexes based on chitosan and alginic acid with the purpose of allocating a combination of chemotherapeutic drugs, improving their efficacy and reducing dosage. In order to enhance targeting, conjugation with folic acid was performed. The prepared carriers exhibited a spherical shape with a diameter in the range 70–120 nm, a ζ-potential between 30 and 35 mV with good stability in human serum, and low hemolytic activity of up to 100 μg/mL. Over 800 μg of drugs per mg of carrier were loaded and released, displaying a pH-dependent trend with no physical, chemical and biological interferences, which benefited from the advantage of having full control over the given release of drug. In vitro studies performed on human epithelial cervix carcinoma cells and mouse fibroblast cells clearly demonstrated that said dual-loaded complexes showed greater cytotoxicity than single-loaded and free-drug formulations. The viability of the cells decreased, thereby confirming the primary role played by the targeting molecule. © 2018 Elsevier B.V.	en
utb.faculty	University Institute
dc.identifier.uri	http://hdl.handle.net/10563/1008095
utb.identifier.obdid	43879678
utb.identifier.scopus	2-s2.0-85049463356
utb.identifier.wok	000445162500009
utb.identifier.coden	JDDSA
utb.source	j-scopus
dc.date.accessioned	2018-08-03T12:49:40Z
dc.date.available	2018-08-03T12:49:40Z
dc.description.sponsorship	VIU-RSCABS-89/2018, TPU, Tomsk Polytechnic University; NPU LO1504; 4.5924.2017, Minobrnauka, Ministry of Education and Science of the Russian Federation
dc.description.sponsorship	Ministry of Education, Youth and Sports of the Czech Republic [NPU LO1504]; Tomsk Polytechnic University [VIU-RSCABS-89/2018]; Russian Ministry of Education and Science [4.5924.2017]
utb.ou	Centre of Polymer Systems
utb.contributor.internalauthor	Di Martino, Antonio
utb.contributor.internalauthor	Sedlařík, Vladimír
utb.fulltext.affiliation	Antonio Di Martino a,b,∗ , Marina E. Trusova b , Pavel S. Postnikov b , Vladimir Sedlarik a a Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic b Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, 634050, Tomsk, Russian Federation ∗ Corresponding author. Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic. E-mail address: dimartino@utb.cz (A. Di Martino).
utb.fulltext.dates	Received 16 March 2018 Received in revised form 23 June 2018 Accepted 24 June 2018 Available online 25 June 2018
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utb.fulltext.sponsorship	This work was funded by the Ministry of Education, Youth and Sports of the Czech Republic (grant no. NPU LO1504), Tomsk Polytechnic University (project VIU-RSCABS-89/2018) and Russian Ministry of Education and Science (Scientific Program no. 4.5924.2017).
utb.scopus.affiliation	Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, Zlin, Czech Republic; Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, Lenin Av. 30, Tomsk, Russian Federation
utb.fulltext.projects	LO1504
utb.fulltext.projects	VIU-RSCABS-89/2018
utb.fulltext.projects	4.5924.2017