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Polyglobalide-based porous networks containing poly(ethylene glycol) structures prepared by photoinitiated thiol-ene coupling
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| dc.title | Polyglobalide-based porous networks containing poly(ethylene glycol) structures prepared by photoinitiated thiol-ene coupling | en |
| dc.contributor.author | Savin, Corina L. | |
| dc.contributor.author | Peptu, Cristian | |
| dc.contributor.author | Kroneková, Zuzana | |
| dc.contributor.author | Sedlačík, Michal | |
| dc.contributor.author | Mrlík, Miroslav | |
| dc.contributor.author | Sasinková, Vlasta | |
| dc.contributor.author | Peptu, Catalina A. | |
| dc.contributor.author | Popa, Marcel | |
| dc.contributor.author | Mosnáček, Jaroslav | |
| dc.relation.ispartof | Biomacromolecules | |
| dc.identifier.issn | 1525-7797 Scopus Sources, Sherpa/RoMEO, JCR | |
| dc.date.issued | 2018 | |
| utb.relation.volume | 19 | |
| utb.relation.issue | 8 | |
| dc.citation.spage | 3331 | |
| dc.citation.epage | 3342 | |
| dc.type | article | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.identifier.doi | 10.1021/acs.biomac.8b00634 | |
| dc.relation.uri | https://pubs.acs.org/doi/10.1021/acs.biomac.8b00634 | |
| dc.description.abstract | The high interest in polymers from natural resources prompted us to investigate the use of enzymatically synthesized polyglobalide (PGL) in the preparation of polymer networks with potential applications as biomaterials for drug delivery devices. Polymer networks were obtained under mild conditions by photoinitiated thiol-ene coupling between PGL and a poly(ethylene glycol-co-thiomalate) (PEG-SH) copolymer obtained by polycondensation. The obtained polymer networks were thoroughly characterized by Raman spectroscopy, scanning electron microscopy, titration of thiol groups and elemental analysis. Our study took into consideration the synthesis parameters for the polymer networks, such as the total polymer concentration and the SH/C=C functionality molar ratio. Swelling in both THF and water was assessed, and the potential of the materials for drug delivery was determined. The scanning electron microscopy images showed that the prepared polymer networks may have different morphologies ranging from homogeneous polymer materials to macroporous structures. Additionally, the prepared materials were found to be suitable from a cytotoxicity point of view, enabling their application as biomaterials for drug delivery devices. © 2018 American Chemical Society. | en |
| utb.faculty | University Institute | |
| dc.identifier.uri | http://hdl.handle.net/10563/1008162 | |
| utb.identifier.obdid | 43879686 | |
| utb.identifier.scopus | 2-s2.0-85048852858 | |
| utb.identifier.wok | 000441852400016 | |
| utb.identifier.pubmed | 29920197 | |
| utb.identifier.coden | BOMAF | |
| utb.source | j-scopus | |
| dc.date.accessioned | 2018-08-30T13:31:23Z | |
| dc.date.available | 2018-08-30T13:31:23Z | |
| dc.description.sponsorship | SASPRO Programme of the Slovak Academy of Sciences [1628/03/02]; People Programme (Marie Curie Actions) European Union's Seventh Framework Programme under REA Grant [609427]; National Scholarship Programme of the Slovak Republic [18428]; Ministry of Education, Youth and Sports of the Czech Republic through program NPU I [LO1504]; [APVV-15-0545]; [VEGA 2/0158/17]; [VEGA 2/0124/18] | |
| utb.ou | Centre of Polymer Systems | |
| utb.contributor.internalauthor | Sedlačík, Michal | |
| utb.contributor.internalauthor | Mrlík, Miroslav | |
| utb.fulltext.affiliation | Corina L. Savin,†,‡ Cristian Peptu,*,†,§ Zuzana Kroneková,† Michal Sedlačík,∥ Miroslav Mrlik,∥ Vlasta Sasinková,⊥ Catalina A. Peptu,‡ Marcel Popa,‡,# and Jaroslav Mosnáček*,† † Polymer Institute of the Slovak Academy of Sciences, Dubravska cesta 9, 84541 Bratislava, Slovakia ‡ Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iaşi, 700050 Iaşi, Romania § “Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487 Iaşi, Romania ∥ Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic ⊥ Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia # Academy of Romanian Scientists, 010071 Bucuresti, Romania | |
| utb.fulltext.dates | Received: April 16, 2018 Revised: June 7, 2018 Published: June 19, 2018 | |
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| utb.fulltext.sponsorship | C.P. acknowledges that this work is financed by the SASPRO Programme of the Slovak Academy of Sciences (Grant Agreement No.: 1628/03/02). Part of the research leading to these results received funding from the People Programme (Marie Curie Actions) European Union’s Seventh Framework Programme under REA Grant Agreement No. 609427. J.M. thanks projects APVV-15-0545 and VEGA 2/0158/17, and the work of Z.K. was also supported by VEGA 2/0124/18. C.S. acknowledges the support of the National Scholarship Programme of the Slovak Republic for the Support of Mobility of Students, Ph.D. Students, University Teachers, Researchers and Artists (Grant Agreement No.: 18428). M.S. and M.M. are thankful for the support of the Ministry of Education, Youth and Sports of the Czech Republic through program NPU I (LO1504). | |
| utb.wos.affiliation | [Savin, Corina L.; Peptu, Cristian; Kronekova, Zuzana; Mosnacek, Jaroslav] Slovak Acad Sci, Inst Polymer, Dubravska Cesta 9, Bratislava 84541, Slovakia; [Savin, Corina L.; Peptu, Catalina A.; Popa, Marcel] Gheorghe Asachi Tech Univ Iasi, Fac Chem Engn & Environm Protect, Dept Nat & Synthet Polymers, Iasi 700050, Romania; [Peptu, Cristian] Petru Poni Inst Macromol Chem, Aleea Grigore Ghica Voda 41A, Iasi 700487, Romania; [Sedlacik, Michal; Mrlik, Miroslav] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Trida T Bati 5678, Zlin 76001, Czech Republic; [Sasinkova, Vlasta] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, Bratislava 84538, Slovakia; [Popa, Marcel] Acad Romanian Scientists, Bucharest 010071, Romania | |
| utb.scopus.affiliation | Polymer Institute, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovakia; Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iaşi, Iaşi, Romania; Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, Iaşi, Romania; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida T. Bati 5678, Zlin, Czech Republic; Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, Slovakia; Academy of Romanian Scientists, Bucuresti, Romania | |
| utb.fulltext.projects | SASPRO 1628/03/02 | |
| utb.fulltext.projects | REA 609427 | |
| utb.fulltext.projects | APVV-15-0545 | |
| utb.fulltext.projects | VEGA 2/0158/17 | |
| utb.fulltext.projects | VEGA 2/0124/18 | |
| utb.fulltext.projects | 18428 | |
| utb.fulltext.projects | LO1504 |
