Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

Škrlová, Kateřina; Rybková, Zuzana; Stachurová, Tereza; Zagora, Jakub; Malachová, Kateřina; Měřínská, Dagmar; Gabor, Roman; Havlíček, Miroslav; Muñoz-Bonilla, Alexandra; Fernández-García, Marta; Plachá, Daniela

dc.title	Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use	en
dc.contributor.author	Škrlová, Kateřina
dc.contributor.author	Rybková, Zuzana
dc.contributor.author	Stachurová, Tereza
dc.contributor.author	Zagora, Jakub
dc.contributor.author	Malachová, Kateřina
dc.contributor.author	Měřínská, Dagmar
dc.contributor.author	Gabor, Roman
dc.contributor.author	Havlíček, Miroslav
dc.contributor.author	Muñoz-Bonilla, Alexandra
dc.contributor.author	Fernández-García, Marta
dc.contributor.author	Plachá, Daniela
dc.relation.ispartof	Polymer Testing
dc.identifier.issn	0142-9418 Scopus Sources, Sherpa/RoMEO, JCR
dc.identifier.issn	1873-2348 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued	2022
utb.relation.volume	116
dc.type	article
dc.language.iso	en
dc.publisher	Elsevier Ltd
dc.identifier.doi	10.1016/j.polymertesting.2022.107760
dc.relation.uri	https://www.sciencedirect.com/science/article/pii/S0142941822002811
dc.subject	polylactide	en
dc.subject	polymer composites	en
dc.subject	antimicrobial effect	en
dc.subject	silver	en
dc.subject	HDTMA	en
dc.subject	HDP	en
dc.subject	stents	en
dc.description.abstract	This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored on vermiculite or graphene oxide matrices in an amount of 1% wt. The prepared samples were characterized by conventional methods, further they were exposed to degradation tests in physiological saline conditions and characterized for their antimicrobial properties using common pathogen microorganisms. It has been proven that the prepared polylactide composites change their antimicrobial effects after being in physiological saline of pH 7 and 9 for 0-6 months. The weight of the composites changed by about 10%, and antimicrobial properties were growing over time. The effectiveness of the composites was confirmed for 6 months at minimum. Therefore, they are suitable for the preparation of temporary stents, catheters or implants suitable for fracture fixation.	en
utb.faculty	Faculty of Technology
dc.identifier.uri	http://hdl.handle.net/10563/1011138
utb.identifier.obdid	43884005
utb.identifier.scopus	2-s2.0-85137723316
utb.identifier.wok	000861129800004
utb.identifier.coden	POTED
utb.source	j-scopus
dc.date.accessioned	2022-09-30T08:34:14Z
dc.date.available	2022-09-30T08:34:14Z
dc.description.sponsorship	European Commission, EC: LINKA20364; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Consejo Superior de Investigaciones Científicas, CSIC: CZ.02.2.69/0.0/0.0/19_073/0016945, DGS/INDIVIDUAL/2020-001
dc.description.sponsorship	MSMT Operational program Research, development and education - European Union; CSIC [CZ.02.1.01/0.0/0.0/17_049/0008441]; MSMT Operational Programme Research, Development and Education [CZ.02.1.01/0.0/0.0/17_049/0008441]; [LINKA20364]; [CZ.02.2.69/0.0/0.0/19_073/0016945]
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.access	openAccess
utb.contributor.internalauthor	Měřínská, Dagmar
utb.fulltext.affiliation	Kateřina Škrlová a, b , Zuzana Rybková c , Tereza Stachurová c , Jakub Zagora a, b , Kateřina Malachová c , Dagmar Mě řinská d , Roman Gabor a , Miroslav Havlíček e , Alexandra Muñoz-Bonilla f , Marta Fernández-García f , Daniela Plachá a, g, * a Nanotechnology Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic b Center of Advanced Innovation Technologies, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic c Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00, Ostrava, Czech Republic d Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, 760 01, Zlín, Czech Republic e Medin,a.s., Nové Město na Moravě, Czech Republic f Institute of Polymer Science and Technology (ICTP-CSIC), Juan de la Cierva 3, 28006, Madrid, Spain g ENET Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic * Corresponding author. Nanotechnology Centre, CEET, VSB - Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic. E-mail address: daniela.placha@vsb.cz (D. Plachá).
utb.fulltext.dates	Received 22 April 2022 Received in revised form 21 July 2022 Accepted 27 August 2022 Available online 5 September 2022
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utb.fulltext.sponsorship	This study was supported by the project no. CZ.02.1.01/0.0/0.0/17_049/0008441 “Innovative Therapeutic Methods of Musculoskeletal System in Accident Surgery” within the MSMT Operational program Research, development and education financed by the European Union, by the project LINKA20364 “Design of novel antimicrobial biobased materials using supercritical fluids processes” financed by CSIC and by the project no. CZ.02.2.69/0.0/0.0/19_073/0016945 within the MSMT Operational Programme Research, Development and Education, under project DGS/INDIVIDUAL/2020-001 ″Development of antimicrobial biobased polymeric material using supercritical fluid technology".
utb.wos.affiliation	[Skrlova, Katerina; Zagora, Jakub; Gabor, Roman; Placha, Daniela] VSB Tech Univ Ostrava, Nanotechnol Ctr, CEET, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic; [Skrlova, Katerina; Zagora, Jakub] VSB Tech Univ Ostrava, Ctr Adv Innovat Technol, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic; [Rybkova, Zuzana; Stachurova, Tereza; Malachova, Katerina] Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava 71000, Czech Republic; [Merinska, Dagmar] Tomas Bata Univ Zlin, Fac Technol, Vavreakova 275, Zlin 76001, Czech Republic; [Havlicek, Miroslav] Medin as, Nove Mesto Na Morave, Czech Republic; [Munoz-Bonilla, Alexandra; Fernandez-Garcia, Marta] Inst Polymer Sci & Technol ICTP CSIC, Juan De La Cierva 3, Madrid 28006, Spain; [Placha, Daniela] VSB Tech Univ Ostrava, ENET Ctr, CEET, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic
utb.scopus.affiliation	Nanotechnology Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, Ostrava-Poruba, 708 00, Czech Republic; Center of Advanced Innovation Technologies, VSB – Technical University of Ostrava, 17. listopadu 2172/15, Ostrava-Poruba, 708 00, Czech Republic; Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, Ostrava, 710 00, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, Zlín, 760 01, Czech Republic; Medin,a.s., Nové Město na Moravě, Czech Republic; Institute of Polymer Science and Technology (ICTP-CSIC), Juan de la Cierva 3, Madrid, 28006, Spain; ENET Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, Ostrava-Poruba, 708 00, Czech Republic
utb.fulltext.projects	CZ.02.1.01/0.0/0.0/17_049/0008441
utb.fulltext.projects	LINKA20364
utb.fulltext.projects	CZ.02.2.69/0.0/0.0/19_073/0016945
utb.fulltext.projects	DGS/INDIVIDUAL/2020-001
utb.fulltext.faculty	Faculty of Technology
utb.fulltext.ou	-
utb.identifier.jel	-