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Aqueous photo-RAFT polymerization under ambient conditions: synthesis of protein-polymer hybrids in open air

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dc.title Aqueous photo-RAFT polymerization under ambient conditions: synthesis of protein-polymer hybrids in open air en
dc.contributor.author Jazani, Arman Moini
dc.contributor.author Murata, Hironobu
dc.contributor.author Cvek, Martin
dc.contributor.author Lewandowska-Andrałojć, Anna
dc.contributor.author Bernat, Roksana
dc.contributor.author Kapil, Kriti
dc.contributor.author Hu, Xiaolei
dc.contributor.author De Luca Bossa, Ferdinando
dc.contributor.author Szczepaniak, Grzegorz
dc.contributor.author Matyjaszewski, Krzysztof
dc.relation.ispartof Chemical Science
dc.identifier.issn 2041-6520 Scopus Sources, Sherpa/RoMEO, JCR
dc.identifier.issn 2041-6539 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2024
utb.relation.volume 15
utb.relation.issue 25
dc.citation.spage 9742
dc.citation.epage 9755
dc.type article
dc.language.iso en
dc.publisher Royal Society of Chemistry
dc.identifier.doi 10.1039/d4sc01409j
dc.relation.uri https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc01409j
dc.relation.uri https://pubs.rsc.org/en/content/articlepdf/2024/sc/d4sc01409j
dc.description.abstract A photoinduced reversible addition-fragmentation chain-transfer (photo-RAFT) polymerization technique in the presence of sodium pyruvate (SP) and pyruvic acid derivatives was developed. Depending on the wavelength of light used, SP acted as a biocompatible photoinitiator or promoter for polymerization, allowing rapid open-to-air polymerization in aqueous media. Under UV irradiation (370 nm), SP decomposes to generate CO2 and radicals, initiating polymerization. Under blue (450 nm) or green (525 nm) irradiation, SP enhances the polymerization rate via interaction with the excited state RAFT agent. This method enabled the polymerization of a range of hydrophilic monomers in reaction volumes up to 250 mL, eliminating the need to remove radical inhibitors from the monomers. In addition, photo-RAFT polymerization using SP allowed for the facile synthesis of protein-polymer hybrids in short reaction times (<1 h), low organic content (≤16%), and without rigorous deoxygenation and the use of transition metal photocatalysts. Enzymatic studies of a model protein (chymotrypsin) showed that despite a significant loss of protein activity after conjugation with RAFT chain transfer agents, the grafting polymers from proteins resulted in a 3-4-fold recovery of protein activity. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1012056
utb.identifier.scopus 2-s2.0-85194187656
utb.identifier.wok 001230537100001
utb.identifier.pubmed 38939137
utb.identifier.coden CSHCC
utb.source j-scopus
dc.date.accessioned 2024-10-22T08:18:26Z
dc.date.available 2024-10-22T08:18:26Z
dc.description.sponsorship Fundacja na rzecz Nauki Polskiej, FNP; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Fonds de recherche du Québec, FRQ; Fonds de recherche du Québec – Nature et technologies, FRQNT, (301734); Fonds de recherche du Québec – Nature et technologies, FRQNT; National Science Foundation, NSF, (CHE 2401112, DMR 2202747); National Science Foundation, NSF; J. W. Fulbright Commission in the Czech Republic, (2022-21-1, RP/CPS/2022/007); Narodowa Agencja Wymiany Akademickiej, NAWA, (BPN/PPO/2022/1/00027); Narodowa Agencja Wymiany Akademickiej, NAWA; Narodowe Centrum Nauki, NCN, (DEC-2023/07/X/ST5/01484); Narodowe Centrum Nauki, NCN
dc.description.sponsorship Fonds de recherche du Quebec (FRQNT) [301734]; J. W. Fulbright Commission in the Czech Republic [2022-21-1]; Project DKRVO [RP/CPS/2022/007]; MEYS of the Czech Republic; National Science Centre within the MINIATURA project [DEC-2023/07/X/ST5/01484]; Foundation for Polish Science (FNP); NSF [CHE 2401112]; [DMR 2202747]
dc.rights Attribution 3.0 Unported
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Cvek, Martin
utb.fulltext.sponsorship A. M. J. acknowledges the Fonds de recherche du Québec (FRQNT) for financial support (File#301734). M. C. is grateful to the J. W. Fulbright Commission in the Czech Republic (grant number: 2022-21-1) and the project DKRVO (RP/CPS/2022/007) supported by MEYS of the Czech Republic for the financial support. R. B. acknowledges financial support from the National Science Centre within the MINIATURA project (DEC-2023/07/X/ST5/01484) and from the Foundation for Polish Science (FNP). G. S. acknowledges the Polish National Agency for Academic Exchange (BPN/PPO/2022/1/00027) for financial support. We gratefully acknowledge support from NSF (DMR 2202747 and CHE 2401112).
utb.wos.affiliation [Jazani, Arman Moini; Murata, Hironobu; Cvek, Martin; Bernat, Roksana; Kapil, Kriti; Hu, Xiaolei; Bossa, Ferdinando De Luca; Szczepaniak, Grzegorz; Matyjaszewski, Krzysztof] Carnegie Mellon Univ, Dept Chem, 4400 Fifth Ave, Pittsburgh, PA 15213 USA; [Cvek, Martin] Tomas Bata Univ Zlin, Ctr Polymer Syst, Trida T Bati 5678, Zlin 76001, Czech Republic; [Lewandowska-Andralojc, Anna] Adam Mickiewicz Univ, Fac Chem, Uniwersytetu Poznanskiego 8, PL-61614 Poznan, Poland; [Lewandowska-Andralojc, Anna] Adam Mickiewicz Univ, Ctr Adv Technol, Uniwersytetu Poznanskiego 10, PL-61614 Poznan, Poland; [Bernat, Roksana] Univ Silesia, Inst Mat Engn, 75 Pulku Piechoty 1A, PL-41500 Chorzow, Poland; [Szczepaniak, Grzegorz] Univ Warsaw, Fac Chem, Pasteura 1, PL-02-093 Warsaw, Poland
utb.scopus.affiliation Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, 15213, PA, United States; Centre of Polymer Systems, Tomas Bata University in Zlin, Trida T. Bati 5678, Zlin, 76001, Czech Republic; Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, Poznan, 61-614, Poland; Center for Advanced Technology, Adam Mickiewicz University, Uniwersytetu Poznanskiego 10, Poznan, 61-614, Poland; Institute of Materials Engineering, University of Silesia, 75 Pulku Piechoty 1A, Chorzow, 41-500, Poland; Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw, 02-093, Poland
utb.fulltext.projects FRQNT File#301734
utb.fulltext.projects 2022-21-1
utb.fulltext.projects DKRVO (RP/CPS/2022/007)
utb.fulltext.projects MINIATURA (DEC-2023/07/X/ST5/01484)
utb.fulltext.projects FNP (BPN/PPO/2022/1/00027)
utb.fulltext.projects NSF (DMR 2202747)
utb.fulltext.projects NSF (CHE 2401112)
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