Terahertz time-domain spectroscopy for studying the kinetics of tissue adhesives

Abstract

This study deals with the kinetics of tissue adhesives used for supporting the hemostasis and wound closure during surgical intervention. There are several types of adhesives of different composition which is closely related with their application. The time of curing plays an important role because some applications may require very fast glue for prompt vessel or wound closure; conversely some situations need slower solidification because of longer manipulation with the glue during surgery. Here, the terahertz time-domain spectroscopy is used for studying the kinetics of the glues. To slow the reaction rate, an oily substance is added to the glue samples. The technique of attenuated total reflection is used in this application; the defined amount of glue sample or its mixture is applied on the silicon crystal and the terahertz response is measured in time. This time dependences are analyzed to find time constants for mathematical description of the glue kinetics. © 2015 COPYRIGHT SPIE.